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- Title
Transcriptional profiling of transurethral resection samples provides insight into molecular mechanisms of hormone refractory prostate cancer.
- Authors
Stoss, O.; Werther, M.; Zielinski, D.; Middel, P.; Jost, N.; Rüschoff, J.; Henkel, T.; Albers, P.
- Abstract
The molecular mechanisms for hormone-resistant prostate cancer progression still remain elusive, mainly due to the limited availability of corresponding tissue. As transurethral resection (TUR) is a common palliative therapy for patients with hormone refractory prostate cancer (HRPC) who have subvesical obstruction, we aimed to demonstrate that TUR samples can be used to identify significantly affected biological pathways during the switch to HRPC using oligonucleotide microarray analysis. Among the most significantly deregulated pathways in HRPC, we observed an induction of oxidative phosphorylation and a repression of cytoskeletal components.Prostate Cancer and Prostatic Diseases (2008) 11, 166–172; doi:10.1038/sj.pcan.4501001; published online 24 July 2007
- Subjects
TRANSURETHRAL prostatectomy; PROSTATECTOMY; URETHRA surgery; HORMONES; PROSTATE cancer
- Publication
Prostate Cancer & Prostatic Diseases, 2008, Vol 11, Issue 2, p166
- ISSN
1365-7852
- Publication type
Article
- DOI
10.1038/sj.pcan.4501001