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- Title
Myocardial infarction and future risk of cancer in the general population-the Tromsø Study.
- Authors
Rinde, Ludvig; Småbrekke, Birgit; Hald, Erin; Brodin, Ellen; Njølstad, Inger; Mathiesen, Ellisiv; Løchen, Maja-Lisa; Wilsgaard, Tom; Brækkan, Sigrid; Vik, Anders; Hansen, John-Bjarne
- Abstract
The association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, death, migration or study end. Crude incidence rates (IRs) and hazard ratios (HRs) for cancer after MI were calculated. During a median follow-up of 15.7 years, 1747 subjects developed incident MI, and of these, 146 suffered from a subsequent cancer. In the multivariable-adjusted model (adjusted for age, sex, BMI, systolic blood pressure, diabetes mellitus, HDL cholesterol, smoking, physical activity and education level), MI patients had 46% (HR 1.46; 95% CI: 1.21-1.77) higher hazard ratio of cancer compared to those without MI. The increased cancer incidence was highest during the first 6 months after the MI, with a 2.2-fold higher HR (2.15; 95% CI: 1.29-3.58) compared with subjects without MI. After a 2-year period without higher incidence rate, MI patients displayed 60% (HR 1.60; 95% CI: 1.27-2.03) higher HR of future cancer more than 3 years after the event. The increased IRs were higher in women than men. Patients with MI had a higher short- and long-term incidence rate of cancer compared to subjects without MI. Our findings suggest that occult cancer and shared risk factors of MI and cancer may partly explain the association.
- Subjects
MYOCARDIAL infarction risk factors; CANCER risk factors; CANCER-related mortality; PHYSICAL activity; DEATH rate
- Publication
European Journal of Epidemiology, 2017, Vol 32, Issue 3, p193
- ISSN
0393-2990
- Publication type
Article
- DOI
10.1007/s10654-017-0231-5