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- Title
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation.
- Authors
Ropelle, Eduardo R.; Pauli, José R.; Prada, Patrícia O.; de Souza, Cláudio T.; Picardi, Paty K.; Faria, Marcel C.; Cintra, Dennys E.; Fernandes, Maria Fernanda de A.; Flores, Marcelo B.; Velloso, Lício A.; Saad, Mario J. A.; Carvalheira, José B. C.
- Abstract
Lifestyle interventions including exercise programmes are cornerstones in the prevention of obesity-related diabetes. In this study, we demonstrate that a single bout of exercise inhibits high-fat diet-induced insulin resistance. Diet-induced obesity (DIO) increased the expression and activity of the protein tyrosine phosphatase 1B (PTP1B) and attenuated insulin signalling in gastrocnemius muscle of rats, a phenomenon which was reversed by a single session of exercise. In addition, DIO was observed to lead to serine phosphorylation of insulin receptor substrate 1 (IRS-1), which was also reversed by exercise in muscle in parallel with a reduction in c-Jun N-terminal kinase (JNK) activity. Thus, acute exercise increased the insulin sensitivity during high-fat feeding in obese rats. Overall, these results provide new insights into the mechanism by which exercise restores insulin sensitivity.
- Publication
Journal of Physiology, 2006, Vol 577, Issue 3, p997
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2006.120006