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- Title
O USO DE AINES, INCLUINDO ASPIRINA, NA PREVENÇÃO PRIMÁRIA DA TOXICIDADE GASTRODUODENAL.
- Authors
VILELA, SOFIA FAGUNDES; MAGALHÃES, ANA LUIZA SANTOS; NETO, GERALDO AGUSTAVO DA FONSECA; SILVA, PEDRO IGOR GONTIJO; MORAIS, FERNANDA GENTIL; MAGALHÃES, ANA CAROLINA SANTOS; CAMPOLINA, GABRIELA ARBEX; GUIMARÂES, BERNARDO CARNEIRO DE SOUSA
- Abstract
Nonsteroidal anti-inflammatory drugs, including lowdose aspirin, cause morbidity related to gastric and duodenal mucosal damage, so the primary prevention of NSAID-induced gastrointestinal toxicity is a relevant clinical issue. The prostaglandin E analogue, misoprostol, H2 receptor antagonists and proton pump inhibitors were evaluated as prophylactic therapies for patients using NSAIDs. In addition, selective COX-2 inhibitors are another strategy for reducing NSAIDrelated gastroduodenal toxicity. Several strategies to prevent ulcers in patients requiring prolonged nonsteroidal anti-inflammatory drugs or low-dose aspirin have concluded that the risk of gastroduodenal toxicity is related to risk factors, the status of the patient's Helicobacter pylori and the specific type and dose of NSAIDs. The ability to modify the risk depends on the clinical environment, although it is preferable to use NSAIDs with the least potential for GI toxicity, all NSAIDs are associated with an increased GI risk.
- Publication
Brazilian Journal of Surgery & Clinical Research, 2021, Vol 34, Issue 3, p42
- ISSN
2317-4404
- Publication type
Article