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- Title
EFICÁCIA DA DOSE ÚNICA NA IMUNIZAÇÃO CONTRA O HPV.
- Authors
CAVALCANTI, ANA CAROLINA DAMASCENO; DE SOUZA, CRISTOVÃO HUGO; MARTINS, GABRIELLA MACHADO; DE PAULA, JÚLIA LIMA SOARES; ROCHA, KARINNE NANCY SENA; DE SOUZA, JOSÉ HELVÉCIO KALIL
- Abstract
The human papilloma virus (HPV) is a sexually transmitted disease of high prevalence and incidence. HPV is associated with cervical cancer and has vaccine plans, as the bivalent vaccine, known as Cervarix, is targeted to the two main types of HPV, the 16 and 18, the quadrivalent vaccine, or Gardasil, is targeted to HPV 6, 11, 16, and 18, the first two of which cause papillomas and the nonvalent vaccine (Gardasil 9), which protects against HPV type 6, 11, 16, 18, 31, 33, 45, 52 and 58. Immunization can be performed in one, two or three doses. Thus, it is known that the single dose is not yet a reality in the context of public health, since it is suggested that a single dose regimen may have limited protection against high grade cervical diseases, trigger low levels of antibodies when compared to 2 and 3 doses and have no evidence of immunogenicity. However, the implementation of a single dose can have benefits in terms of the obstacles that multiple vaccine doses entail, such as the difficulty in logistics to establish substantial herd immunity and financial issues, and thus protect against one of the major causes of in the world that lead to death in women. It suggests that up to one dose may be sufficient for protection against HPV-related diseases and greater protection when compared to those who did not receive immunization. Evidence of the lower efficacy of the single dose of the vaccine is not useful to replace the 2 and 3 vaccine doses but rather to complement and emphasize the protection of risk groups and the development of lesions secondary to HPV infection, resources to health, where a single dose would be sufficient to prevent harm to women's health.
- Publication
Brazilian Journal of Surgery & Clinical Research, 2019, Vol 28, Issue 1, p61
- ISSN
2317-4404
- Publication type
Article