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- Title
AVALIAÇÃO DE PACIENTES COM AUMENTO DO CLEARANCE RENAL EM UTI EM USO DE ANTIMICROBIANOS.
- Authors
SCHAIA ROCHA, ANDRESSA; DOS SANTOS, RAFAELLE SCHRAM; BAGLIE, SINVALDO; MIYOSHI, EDMAR
- Abstract
The objective was to identify and characterize patients with augmented renal clearance (ARC), hospitalized in ICU, using antimicrobial. It was a retrospective observational study in a public hospital in Ponta Grossa, Paraná, Brazil, with data collected from medical prescriptions and electronic medical records of patients admitted to an adult ICU. Elderly patients or patients with insufficient data were excluded from the study. Renal function was analyzed through the Cockcroft & Gault formula and the data collected were submitted to descriptive analysis. During the period, of 71 patients analyzed, 15 (21%) patients presented ARC. Of the patients with ACR, 11 (73%) were men with a mean age of 34.1 years. In this period, 47 antimicrobials were prescribed, with an average of 3 antimicrobials per individual. Many of these suffer renal excretion and dose adjustments are necessary in ARC. Among them, third-generation cephalosporins were the most prescribed class (29.8%). In this study, it was demonstrated that ICU patients presented ARC and that there was no modification in the dosage of antimicrobials. It is expected that patients with ARC will be reevaluated and that adjusting renal elimination antimicrobial dose is a practice, when necessary, avoiding underexposure to the antimicrobial and for the treatment to be more effective, reducing bacterial resistance.
- Publication
Brazilian Journal of Surgery & Clinical Research, 2017, Vol 18, Issue 3, p37
- ISSN
2317-4404
- Publication type
Article