We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis.
- Authors
Hamrun, Nurlindah; Ruslin, Muhammad; Marlina, Erni; Oktawati, Sri; Saito, Takashi; Yusuf, Andi Sitti Hajrah; Ou, Keng-Liang
- Abstract
The present study aimed to assess the incidence of the vitamin D receptor (VDR) gene polymorphism TaqI in patients with periodontitis, and the potential association of this polymorphism with the severity of the disease. This was a case-controlled study, which included 162 adults divided into two groups as follows: Case group (81 patients diagnosed with periodontitis) and control group (81 patients without periodontitis). Venous blood was obtained from each sample from which DNA was extracted. The gene polymorphism was determined using restricted fragment length polymorphism-PCR and DNA sequencing to identify endonuclease restrictions in exon 9 (TaqI). The data were analyzed using an independent samples t-test. VDR gene polymorphisms were detected in periodontitis cases with TT (86.4%), Tt (12.4%) and tt (1.2%) genotypes. DNA sequencing confirmed a change in the sequence of the VDR gene nucleotides in patients with periodontitis. The data indicated that the severity of periodontal tissue damage may be influenced by changes in the nucleotide sequence.
- Subjects
VITAMIN D receptors; PERIODONTITIS; GENETIC polymorphisms; NUCLEOTIDE sequence; DNA sequencing
- Publication
Biomedical Reports, 2022, Vol 16, Issue 5, pN.PAG
- ISSN
2049-9434
- Publication type
Article
- DOI
10.3892/br.2022.1518