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- Title
Interleukin 12 production by monocytes from patients with psoriasis and its inhibition by ciclosporin A.
- Authors
Tada, Y.; Asahina, A.; Takekoshi, T.; Kishimoto, E.; Mitsui, H.; Saeki, H.; Komine, M.; Tamaki, K.
- Abstract
Background Psoriasis is a T-helper (Th)1 cytokine-mediated chronic skin disease and interleukin (IL)-12 has been shown to play a major role in the development of Th1 responses. Objectives To elucidate the role of IL-12 in the pathogenesis of psoriasis and to study the effect of ciclosporin A (CsA) on Th1 deviation of this disease. Patients/Methods We investigated IL-12 production by stimulated monocytes from patients with psoriasis who were treated with or without CsA. Monocytes were stimulated with interferon- γ plus lipopolysaccharide (LPS) or Staphylococcus aureus Cowan strain I (SAC). The amount of IL-12 p70 produced by stimulated monocytes was evaluated by enzyme-linked immunosorbent assay. Results Compared with those from normal controls, LPS- but not SAC-stimulated monocytes from patients with psoriasis produced significantly higher amounts of IL-12. Interestingly, LPS-stimulated monocytes from patients with psoriasis treated with CsA produced significantly decreased amounts of IL-12 compared with those patients not treated with CsA. Conclusions Our results suggest that IL-12 production by monocytes may have a critical role in the pathogenesis of psoriasis, and that the therapeutic effect of CsA on psoriasis may be achieved by correcting the deviation of the Th1/Th2 balance.
- Subjects
PSORIASIS; INTERLEUKIN-12; MONOCYTES; SKIN diseases; STAPHYLOCOCCUS aureus; CELLULAR immunity
- Publication
British Journal of Dermatology, 2006, Vol 154, Issue 6, p1180
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.2006.07180.x