We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A study of the sequential clinical and pathological changes during proliferative kidney disease in rainbow trout, <em>Salmo gairdneri</em> Richardson.
- Authors
Clifton-Hadley, R. S.; Bucke, D.; Richards, R. H.
- Abstract
A histological study of 0+ rainbow trout, exposed to proliferative kidney disease (PKD) on art infected farm, showed evidence of infection from the beginning of June, gross pathological changes from the beginning of July, and clinical signs from mid-July. Evidence of healing was present in some samples from the second week of August. Kidney samples were divided into five grades (0-4) representing increasing severity of pathology. A sixth grade (H) was applied to kidneys showing signs of healing. The most frequent clinical signs were abdominal distension and exophthalmos. Melanosis, cornea! cloudiness and ecchymoses were observed occasionally. Apart from renal enlargement, other internal gross pathological changes included ascites, gill and liver pallor. oedema, petechiation, and splenic enlargement. The majority of clinical signs and internal changes were only seen in fish with advanced renal swelling (grades 3 and 4). Histopathology was most marked in the kidney and was of three types: haemopoietic hyperplasia, vascular pathology and diffuse inflammatory change. Vascular changes, including occlusion of blood vessels in several organs and apparent haemoglobin crystallization, and destruction of renal excretory structures within areas of chronic diffuse inflammation were marked features of the histopathology in fish with clinical signs. The pathogenesis of PKD is discussed with reference to the histopathological changes.
- Subjects
KIDNEY diseases; FISH diseases; RAINBOW trout; PATHOLOGY; PREVENTIVE medicine; HISTOPATHOLOGY
- Publication
Journal of Fish Diseases, 1987, Vol 10, Issue 5, p335
- ISSN
0140-7775
- Publication type
Article
- DOI
10.1111/j.1365-2761.1987.tb01081.x