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- Title
Vasorelaxant Effect of Ethanolic Extracts from M. Vulgare: Mexican Medicinal Plant as Potential Source for Bioactive Molecules Isolation.
- Authors
Jorge, Vergara-Galicia; Melina, Huerta-García; Joaquín, Herrera-Chi; Patricia, Castillo-España; Emmanuel, Reyes-Martínez; Marisa, Estrada-Carrillo; Samuel, Estrada-Soto; Ángel, Sierra-Ovando; Emmanuel, Hernandez-Nuñez
- Abstract
To investigate vasorelaxant effect of ethanol extracts from M. vulgare, it is part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects. In this context, all extracts caused concentration-dependent relaxation in -precontracted aortic rings with and without endothelium; the most active extract was EERMv. These results suggest that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of high polarity and the roots were the main tissues of the plant where the vasorelaxant compounds are stored. In conclusion, M. vulgare represent an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.
- Subjects
ETHANOL; PHYTOCHEMICALS; MEDICINAL plants; MARRUBIUM vulgare; LEAD compounds; ANTIHYPERTENSIVE agents; PLANT extracts
- Publication
Indo Global Journal of Pharmaceutical Sciences, 2013, Vol 3, Issue 1, p1
- ISSN
2249-1023
- Publication type
Article
- DOI
10.35652/igjps.2013.01