We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Structural and Functional Brain Changes in Migraine.
- Authors
Ashina, Sait; Bentivegna, Enrico; Martelletti, Paolo; Eikermann-Haerter, Katharina
- Abstract
Migraine is a prevalent primary headache disorder and is usually considered as benign. However, structural and functional changes in the brain of individuals with migraine have been reported. High frequency of white matter abnormalities, silent infarct-like lesions, and volumetric changes in both gray and white matter in individuals with migraine compared to controls have been demonstrated. Functional magnetic resonance imaging (MRI) studies found altered connectivity in both the interictal and ictal phase of migraine. MR spectroscopy and positron emission tomography studies suggest abnormal energy metabolism and mitochondrial dysfunction, as well as other metabolic changes in individuals with migraine. In this review, we provide a brief overview of neuroimaging studies that have helped us to characterize some of these changes and discuss their limitations, including small sample sizes and poorly defined control groups. A better understanding of alterations in the brains of patients with migraine could help not only in the diagnosis but may potentially lead to the optimization of a targeted anti-migraine therapy.
- Subjects
PRIMARY headache disorders; FUNCTIONAL magnetic resonance imaging; MIGRAINE; POSITRON emission tomography; EMISSION spectroscopy
- Publication
Pain & Therapy, 2021, Vol 10, Issue 1, p211
- ISSN
2193-8237
- Publication type
Article
- DOI
10.1007/s40122-021-00240-5