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- Title
Survival of patients with documented autologous recovery after SCT for severe aplastic anemia: a study by the WPSAA of the EBMT.
- Authors
Piccin, A.; McCann, S.; Socié, G.; Oneto, R.; Bacigalupo, A.; Locasciulli, A.; Marsh, J.; Schrezenmeier, H.; Tichelli, A.; Hand, E.; Lawler, M.; Passweg, J.
- Abstract
Graft rejection, with persistent pancytopenia, is well documented after allogeneic BMT (hematopoietic SCT (HSCT)) for severe aplastic anemia (SAA) and the prognosis is poor. The recovery of host-hematopoiesis, autologous recovery (AR), after allogeneic HSCT is a rare event and the incidence and long-term survival are unknown. We report a retrospective analysis of consecutive patients in the Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT–WPSAA) registry between 1973 and 2005. A total of 45 cases of AR, of 1205 patients transplanted for SAA in 57 centers are reported. We describe characteristics and long-term outcome of patients with AR, compared with SAA patients from participating transplant centers without AR (n=1024) and patients with graft rejection (n=136) without autologous recovery. The estimated cumulative incidence of AR was 4.2% (3.1–5.6) (confidence interval (CI) 95%) with an OS of 84% (95% CI 83–107%). The OS of the control group was 74% (81–90) at 10 years of follow up, whereas the patients with graft failure had an OS of 16% (CI 12–28%). This retrospective analysis establishes the incidence and long-term survival of patients experiencing AR after allogeneic HSCT for SAA.
- Subjects
GRAFT rejection; APLASTIC anemia; PROGNOSIS; BLOOD; HEMATOPOIESIS; BONE marrow
- Publication
Bone Marrow Transplantation, 2010, Vol 45, Issue 6, p1008
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/bmt.2009.296