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- Title
Association at SYNE1 in both bipolar disorder and recurrent major depression.
- Authors
Green, E K; Grozeva, D; Forty, L; Gordon-Smith, K; Russell, E; Farmer, A; Hamshere, M; Jones, I R; Jones, L; McGuffin, P; Moran, J L; Purcell, S; Sklar, P; Owen, M J; O'Donovan, M C; Craddock, N
- Abstract
Genome-wide association studies (GWAS) have identified a number of loci that have strong support for their association with bipolar disorder (BD). The Psychiatric Genome-Wide Association Study (GWAS) Consortium Bipolar Disorder Working Group (PGC-BD) meta-analysis of BD GWAS data sets and replication samples identified evidence (P=6.7 × 10−7, odds ratio (OR)=1.147) of association with the risk of BD at the polymorphism rs9371601 within SYNE1, a gene which encodes nesprin-1. Here we have tested this polymorphism in an independent BD case (n=1527) and control (n=1579) samples, and find evidence for association (P=0.0095) with similar effect sizes to those previously observed in BD (allelic OR=1.148). In a combined (meta) analysis of PGC-BD data (both primary and replication data) and our independent BD samples, we found genome-wide significant evidence for association (P=2.9 × 10−8, OR=1.104). We have also examined the polymorphism in our recurrent unipolar depression cases (n=1159) and control (n=2592) sample, and found that the risk allele was associated with risk for recurrent major depression (P=0.032, OR=1.118). Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders.
- Subjects
BIPOLAR disorder; AFFECTIVE disorders; META-analysis; GENETIC polymorphisms; GENOMES
- Publication
Molecular Psychiatry, 2013, Vol 18, Issue 5, p614
- ISSN
1359-4184
- Publication type
Article
- DOI
10.1038/mp.2012.48