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- Title
Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients.
- Authors
Serretti, A.; Kato, M.; De Ronchi, D.; Kinoshita, T.
- Abstract
The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate, response rate and response rate within 4 weeks using the cochrane review manager. We observed a significant association of the s/s variant of 5-HTTLPR with remission rate (P<0.0001) and both s/s and s/l variants with response rate (P=0.0002). Response rate within 4 weeks was associated in both models (P=0.003–P<0.00001). This effect is quite robust to ethnic differences although a significant heterogeneity is present in Asian samples.Molecular Psychiatry (2007) 12, 247–257. doi:10.1038/sj.mp.4001926; published online 5 December 2006
- Subjects
META-analysis; SEROTONIN; GENETIC polymorphisms; MENTAL depression; AFFECTIVE disorders; PATHOLOGICAL psychology
- Publication
Molecular Psychiatry, 2007, Vol 12, Issue 3, p247
- ISSN
1359-4184
- Publication type
Article
- DOI
10.1038/sj.mp.4001926