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- Title
Impact of HIV‐1 viremia or sexually transmitted infection on semen‐derived anti‐HIV‐1 antibodies and the immunosuppressive capacity of seminal plasma.
- Authors
Selva, Kevin J.; Bavinton, Benjamin R.; Grulich, Andrew E.; Pazgier, Marzena; Kelleher, Anthony D.; Kent, Stephen J.; Parsons, Matthew S.
- Abstract
Impact of HIV-1 viremia or sexually transmitted infection on semen-derived anti-HIV-1 antibodies and the immunosuppressive capacity of seminal plasma Anti-HIV-1 antibodies, derived from SP (n = 11) or within paired blood sera samples (n = 11) from HIV-1-infected donors, were assessed for anti-HIV-1 antibody-dependent NK cell activation capacity. (C) The relationship between anti-HIV-1 antibody-dependent NK cell activation triggered by anti-HIV-1 antibodies within paired pre-ART blood sera and SP. D, the presence of A32 Fab significantly inhibited anti-HIV-1 antibody-dependent NK cell activation triggered by IgG derived from SP samples (used at equivalent of a 1:10 dilution) from nine HIV-1-infected donors [70.90% inhibition (14.03-87.13%), I p i = 0.004].
- Subjects
SEXUALLY transmitted diseases; ANTIBODY-dependent cell cytotoxicity; IMMUNOGLOBULINS; KILLER cells; BLOOD plasma; RITUXIMAB
- Publication
European Journal of Immunology, 2019, Vol 49, Issue 12, p2255
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201848055