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- Title
Human CD4+ T cells maintain specific functions even under conditions of extremely restricted ATP production.
- Authors
Tripmacher, Robert; Gaber, Timo; Dziurla, René; Häupl, Thomas; Erekul, Kerem; Grützkau, Andreas; Tschirschmann, Miriam; Scheffold, Alexander; Radbruch, Andreas; Burmester, Gerd-Rüdiger; Buttgereit, Frank
- Abstract
We investigated the energy-adaptive potential of human CD4 T cells under conditions of impaired oxidative phosphorylation (OXPHOS) and/or low glucose (inhibiting glycolysis). These cells often encounter these conditions when executing their functions in injured/inflamed tissues, even though T cells themselves require constant and adequate energy supply via ATP. We assessed two specific functions, cytokine synthesis and proliferation, and addressed whether adaptive characteristics also emerged in vivo. In glucose-containing medium, both cytokine production and proliferation were unaffected, even under complete OXPHOS suppression. Only when glucose was also absent were these functions significantly decreased. Partial recovery of OXPHOS and induced glycolysis were crucial for the maintenance of cellular energy supply. Adaptive regulatory mechanisms are clinically relevant because hypoxia up-regulates glycolytic genes but down-regulates OXPHOS genes in vivo. Our data demonstrate an unexpectedly high, clinically relevant adaptive potential of human CD4 T cells to maintain specific functions even under severely impaired bioenergetic conditions. Supporting Information for this article is available at www.wiley-vch.de/contents/jc_2040/200838047_s.pdf
- Publication
European Journal of Immunology, 2008, Vol 38, Issue 6, p1631
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200738047