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- Title
Factors Affecting Potency of Hemorrhagic Septicemia Vaccines.
- Authors
Sarwar, Noreen; Muhammad, Khushi; Rabbani, Masood; Rana, Muhammad Younus; Sarwar, Mobeen; Ali, Muhammad Asad; Nazir, Jawad; Kamran, Muhammad
- Abstract
This study was aimed at investigating effects of biomass, adjuvant, storage, priming alone or with boosting of an inactivated Haemorrhagic Septicemia (HS) vaccine (prepared from dense growth of Pasteurella multocida) on its potency using indirect hem-agglutination (IHA) test. The vaccine containing dry mass 1.7 mg/dose or bacterial count 1014/dose was sufficient to induce protective antibody titer (GMT=log 25.2). Montanide ISA 70 based HS vaccine induced better antibody response (GMT=log 26) in buffalo calves than that of HS vaccine containing aluminum hydroxide gel (GMT=log 23.2) or no adjuvant (undetectable). The oil based HS vaccine remained potent (GMT=log 23.8) even after storage at 40C for eight months. Boosting of calves with oil based HS vaccine may help keep the calves immunized for 12 months. It was concluded that the proposed study improved quality of the vaccine and reduced the vaccine volume per dose, cost of its production and frequency of the vaccination. © 2015 Friends Science Publishers
- Subjects
HEMORRHAGIC septicemia; VACCINES; PASTEURELLA multocida; SARWAR, Noreen; MUHAMMAD, K.; RANA, M. Y.
- Publication
International Journal of Agriculture & Biology, 2015, Vol 17, Issue 2, p387
- ISSN
1560-8530
- Publication type
Article