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- Title
Ligand migration in human indoleamine-2,3 dioxygenase.
- Authors
Nienhaus, Karin; Nickel, Elena; Lu, Changyuan; Yeh, Syun-Ru; Nienhaus, G. Ulrich
- Abstract
Human indoleamine 2,3-dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L-tryptophan (L-Trp) and other indoleamine derivatives. Its activity follows typical Michaelis-Menten behavior only for L-Trp concentrations up to 50 μM; a further increase in the concentration of L-Trp causes a decrease in the activity. This substrate inhibition of hIDO is a result of the binding of a second L-Trp molecule in an inhibitory substrate binding site of the enzyme. The molecular details of the reaction and the inhibition are not yet known. In the following, we summarize the present knowledge about this heme enzyme. © 2011 IUBMB IUBMB Life, 63(3): 153-159, 2011
- Subjects
LIGANDS (Biochemistry); HEMOPROTEINS; FOURIER transform infrared spectroscopy; SPECTRUM analysis; ENZYMES; HEME
- Publication
IUBMB Life, 2011, Vol 63, Issue 3, p153
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.431