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- Title
PLGA-LECITHIN-PEG CORE-SHELL NANOPARTICLES FOR CANCER TARGETED THERAPY.
- Authors
ZHENG, MINGBIN; GONG, PING; JIA, DONGXUE; ZHENG, CUIFANG; MA, YIFAN; CAI, LINTAO
- Abstract
We reported the development of multifunctional poly (lactic-co-glycolic acid) (PLGA)-lecithin-polyethylene glycol (PEG) core-shell nanoparticles (NPs) that combined the beneficial properties of liposome and polymeric NPs for chemotherapeutics delivery. The particle size, surface charge and surface functional groups were easily tunable in highly reproducible manner by various formulation parameters such as lipid/polymer, 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-PEG-/lecithin, DSPE-PEG-/DSPE-PEG- mass ratio and modification of terminal groups of DSPE-PEG. We encapsulated model chemotherapy drug, hydrophilic cisplatin (DDP) or hydrophobic DDP prodrug, in the NPs and showed high encapsulation efficiency, excellent stability, specific FA targeting recognition for MCF-7 cells with over FA receptors expression and pretty cytotoxicity. Such PLGA-lecithin-PEG core-shell nanoparticles (NPs) were proved to be a promising drug delivery nanocarrier for cancer-targeted therapy.
- Publication
Nano Life, 2012, Vol 2, Issue 1, p-1
- ISSN
1793-9844
- Publication type
Article
- DOI
10.1142/S1793984411000359