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- Title
Baculovirus-mediated Gene Delivery and RNAi Applications.
- Authors
Makkonen, Kaisa-Emilia; Airenne, Kari; Ylä-Herttulala, Seppo
- Abstract
Baculoviruses are widely encountered in nature and a great deal of data is available about their safety and biology. Recently, these versatile, insect-specific viruses have demonstrated their usefulness in various biotechnological applications including protein production and gene transfer. Multiple in vitro and in vivo studies exist and support their use as gene delivery vehicles in vertebrate cells. Recently, baculoviruses have also demonstrated high potential in RNAi applications in which several advantages of the virus make it a promising tool for RNA gene transfer with high safety and wide tropism.
- Subjects
BACULOVIRUSES; INSECT viruses; BACULOVIRUS diseases; RNA interference; ARGONAUTE proteins
- Publication
Viruses (1999-4915), 2015, Vol 7, Issue 4, p2099
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v7042099