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- Title
Complete Genome Analysis of a Rabbit Rotavirus Causing Gastroenteritis in a Human Infant.
- Authors
Bonica, Melisa Berenice; Zeller, Mark; Van Ranst, Marc; Matthijnssens, Jelle; Heylen, Elisabeth
- Abstract
Group A rotaviruses (RVA) are responsible for causing infantile diarrhea both in humans and animals. The molecular characteristics of lapine RVA strains are only studied to a limited extent and so far G3P[14] and G3P[22] were found to be the most common G/P- genotypes. During the 2012-2013 rotavirus season in Belgium, a G3P[14] RVA strain was isolated from stool collected from a two-year-old boy. We investigated whether RVA/Human-wt/BEL/BE5028/2012/G3P[14] is completely of lapine origin or the result of reassortment event(s). Phylogenetic analyses of all gene segments revealed the following genotype constellation: G3-P[14]-I2-R2-C2-M3-A9-N2-T6-E5-H3 and indicated that BE5028 probably represents a rabbit to human interspecies transmission able to cause disease in a human child. Interestingly, BE5028 showed a close evolutionary relationship to RVA/Human-wt/BEL/B4106/2000/G3P[14], another lapine-like strain isolated in a Belgian child in 2000. The phylogenetic analysis of the NSP3 segment suggests the introduction of a bovine(-like) NSP3 into the lapine RVA population in the past 12 years. Sequence analysis of NSP5 revealed a head-to-tail partial duplication, combined with two short insertions and a deletion, indicative of the continuous circulation of this RVA lineage within the rabbit population.
- Subjects
GENOMICS; ROTAVIRUSES; REOVIRUSES; GASTROENTERITIS in children; DISEASE vectors
- Publication
Viruses (1999-4915), 2015, Vol 7, Issue 2, p844
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v7020844