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- Title
The Role of Equine Herpesvirus Type 4 Glycoprotein K in Virus Replication.
- Authors
Azab, Walid; El-Sheikh, Abuelyazeed
- Abstract
Equine herpesvirus 4 (EHV-4) is an important equine pathogen that causes respiratory tract disease among horses worldwide. Glycoprotein K (gK) homologues have been identified in several alphaherpesviruses as a major player in virus entry, replication, and spread. In the present study, EHV-4 gK-deletion mutant has been generated by using bacterial artificial chromosome technology and Red mutagenesis to investigate the role of gK in EHV-4 replication. Our findings reported here show that gK is essential for virus replication in vitro and that the gK-negative strain was not able to be reconstituted in equine cells. It is noteworthy that these findings agree with the previously published study describing gK deletion in other alphaherpesviruses.
- Subjects
EQUINE herpesvirus diseases; HORSE diseases; GLYCOPROTEINS; VIRAL replication; MUTAGENESIS; HERPESVIRUS diseases in animals
- Publication
Viruses (1999-4915), 2012, Vol 4, Issue 8, p1258
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v4081258