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- Title
Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences.
- Authors
Bertazzoni, Umbert; Turci, Marco; Avesani, Francesca; di Gennaro, Gianfranco; Bidoia, Carlo; Romanelli, Maria Grazia
- Abstract
Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ in their cellular localization and in their interaction pattern with cellular factors? In this review, we summarize Tax-1 and Tax-2 structural and phenotypic properties, their interaction with factors involved in signal transduction and their localization-related behavior within the cell. Special attention will be given to the distinctions between Tax-1 and Tax-2 that likely play an important role in their transactivation activity.
- Subjects
HTLV-I; CELLULAR signal transduction; PROTEINS; HTLV-II (Virus); CELLULAR control mechanisms
- Publication
Viruses (1999-4915), 2011, Vol 3, Issue 5, p541
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v3050541