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- Title
Paradoxical Interplay of Viral and Cellular Functions.
- Authors
Domingo, Esteban
- Abstract
Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens [1]. The dual implication of key cellular functions in the innate immunity against viruses, or, paradoxically, as mediators of virus replication is interpreted in the light of the concept of virus-host coevolution and tinkering proposed for general evolution by François Jacob decades ago.
- Subjects
VIRAL replication; CELL physiology; LIFE cycles (Biology); ADENOSINE deaminase; RNA viruses; EMBRYOLOGY
- Publication
Viruses (1999-4915), 2011, Vol 3, Issue 3, p272
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v3030272