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- Title
Structures of Reverse Transcriptase Pre- and Post-Excision Complexes Shed New Light on HIV-1 AZT Resistance.
- Authors
Scott, Walter A.
- Abstract
HIV-1 resistance to 3′-azido-2′,3′-deoxythymidine (AZT, zidovudine) results from mutations in reverse transcriptase that increase the ability of the enzyme to excise AZT-monophosphate after it has been incorporated. Crystal structures of complexes of wild type and mutant reverse transcriptase with double-stranded DNA with or without the excision product, AZT adenosine dinucleoside tetraphosphate (AZTppppA), have recently been reported [1]. The excision-enhancing mutations dramatically change the way the enzyme interacts with the excision product.
- Subjects
DRUG resistance; AZIDOTHYMIDINE; HIV infections; HIV; DNA; NUCLEOTIDES
- Publication
Viruses (1999-4915), 2011, Vol 3, Issue 1, p20
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v3010020