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- Title
Tumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Elderly Patients With Breast Cancer.
- Authors
NIKOLAIDI, ADAMANTIA; KOTOULA, VASSILIKI; KOLIOU, GEORGIA-ANGELIKI; GIANNOULATOU, ELENI; PAPADOPOULOU, KYRIAKI; ZAGOURI, FLORA; PENTHEROUDAKIS, GEORGE; GOGAS, HELEN; BOBOS, MATTHEOS; CHATZOPOULOS, KYRIAKOS; OIKONOMOPOULOS, GEORGIOS; PECTASIDES, DIMITRIOS; SALOUSTROS, EMMANOUIL; ARNOGIANNAKI, NIKI; NICOLAOU, IRENE; PAPAKOSTAS, PAVLOS; BOMPOLAKI, ILIADA; ARAVANTINOS, GERASIMOS; ATHANASIADIS, ILIAS; FOUNTZILAS, GEORGE
- Abstract
Background/Aim: Age may pertain to different tumor genotype characteristics which may interfere with treatment efficacy and prognosis. We investigated the distribution and prognostic effect of mutations and tumor infiltrating lymphocyte (stromal TIL density) in young (=35 years) and elderly (>65 years) early breast cancer patients. Materials and Methods: Paraffin tumor genotypes of all clinical subtypes from 345 patients were examined. Results: A total of 638 mutations were detected in 221 patients (64.1%). Compared to young, elderly patients presented with lower TIL density (p<0.001) but moreTILs in TP53 mutated tumors (p=0.042). Mutation in one, rather than in 2 or more genes, conferred better outcome (DFS: HR=0.51, p=0.016; OS: HR=0.47, p=0.015) but the effect was age-independent. Conclusion: There are fewer TILs and different mutations patterns in tumors from elderly patients compared to young. Age and TIL-independent gene agnostic co-mutations affect patient outcome.
- Subjects
OLDER patients; BREAST cancer; CANCER patients; LYMPHOCYTES; DENSITY
- Publication
Cancer Genomics & Proteomics (1109-6535), 2020, Vol 17, Issue 2, p181
- ISSN
1109-6535
- Publication type
Article
- DOI
10.21873/cgp.20179