We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reversal of nonresponders and postexposure prophylaxis by intradermal hepatitis B vaccination in Japanese medical personnel.
- Authors
Nagafuchi, Seiho; Kashiwagi, Seizaburo; Okada, Kenji; Anzai, Keizo; Nakamura, Minoru; Nishimura, Yasuharu; Sasazuki, Takehiko; Niho, Yoshiyuki; Nagafuchi, S; Kashiwagi, S; Okada, K; Anzai, K; Nakamura, M; Nishimura, Y; Sasazuki, T; Niho, Y
- Abstract
Thirty-one Japanese nonresponders to subcutaneous hepatitis B vaccination and 15 medical personnel who were accidentally exposed to specimens positive for hepatitis B e antigen and were given hepatitis B immunoglobulin were intradermally immunized with 5 micrograms of plasma-derived hepatitis B vaccine every 2 weeks until delayed type hypersensitivity skin reaction to hepatitis B surface antigen became positive. Thirty (97%) of the 31 nonresponders developed delayed type hypersensitivity skin reactions to hepatitis B surface antigen after 2.3 +/- 1.2 (mean +/- SD) revaccinations. Twenty-nine (94%) of the 31 nonresponders had anti-hepatitis B surface antigen antibody levels greater than 10 IU/L. The immunoglobulin subclass of the antibody to hepatitis B surface antigen was mainly IgG1. After 1 year, 23 (74%) of the 31 nonresponders continued to have anti-hepatitis B surface antigen antibody levels greater than 10 IU/L. Persons accidentally exposed to specimens positive for hepatitis B e antigen developed delayed type hypersensitivity skin reactions to hepatitis B surface antigen following 3.1 +/- 1.1 revaccinations. None developed clinical hepatitis. There was no production of anti-hepatitis B core antigen antibody 1 year after exposure, indicating that protection was 100%. Intradermal hepatitis B vaccination is useful in reversing nonresponsiveness to hepatitis B surface antigen and for prophylaxis after exposure.
- Subjects
HEPATITIS B; VACCINATION; CELL surface antigens; IMMUNOGLOBULINS; IMMUNIZATION; RESEARCH
- Publication
JAMA: Journal of the American Medical Association, 1991, Vol 265, Issue 20, p2679
- ISSN
0098-7484
- Publication type
journal article
- DOI
10.1001/jama.1991.03460200059035