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- Title
Chemical Constituents of the Whole Plant of Verbena hastata and Their Inhibitory Activity Against the Production of AGEs.
- Authors
Akihito Yokosuka; Misaki Honda; Hitoshi Kondo; Yoshihiro Mimaki
- Abstract
1, 1, 1, and 1Two iridoid glycosides (1 and 2), 3 phenolic glycosides (3-5), 1 flavone glycoside (6), 3 biflavonoids (7-9), 1 flavone (10), 2 triterpenes (11 and 12), 1 sterol (13), and 1 naphthoquinone derivative (14) were isolated from the whole plant of Verbena hastata (Verbenaceae). Compounds 3-13 were isolated from V. hastata for the first time. Compound 14 is undescribed in the literature. Incubation of glyceraldehyde and collagen either with phenolic glycosides (3), (4), or (5) or with biflavonoid (8) inhibited the production of advanced glycation end products, with IC50 values of 6.3, 6.4, 6.2, and 6.8 mM, respectively. Aminoguanidine, which was used as a positive control, had an IC50 value of 10.2 mM.
- Subjects
IRIDOIDS; VERBENA; FLAVONE glycosides; STEROLS; AMINOGUANIDINE
- Publication
Natural Product Communications, 2021, Vol 16, Issue 4, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X211009727