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- Title
Effects of different concentrations of coated nano zinc oxide material on fecal bacterial composition and intestinal barrier in weaned piglets.
- Authors
Liu, Hongnan; Bai, Miaomiao; Xu, Kang; Zhou, Jian; Zhang, Xiaofeng; Yu, Rong; Huang, Ruilin; Yin, Yulong
- Abstract
BACKGROUND: Coated nano zinc oxide (Cnz) is a new feed or food additive, which is a potential replacement for a pharmacological dose level of ZnO. This study evaluated the positive effects of different concentrations of Cnz on the intestinal bacterial core, enterobacterial composition and mucosal barrier function in a pig model. RESULTS: Microbiota sequencing results showed that Cnz could significantly alter the intestinal microbiota composition and metabolism. Besides increasing the richness indices (ACE and Chao1), 10% Cnz could protect the intestinal mucosal barrier through increasing the expression of occludin and zonula occludens‐1 in the small intestine, increase the abundance of Lachnospiraceae UCG‐004 and decrease the abundance of Ruminococcus flavefaciens compared to high ZnO diet and 5% Cnz material. CONCLUSIONS: Cnz material at 10% supplementation is more effective than a level of 5% Cnz in increasing intestinal barrier through affecting gut microbiota. © 2020 Society of Chemical Industry
- Subjects
SOCIETY of Chemical Industry (Great Britain); FECES; PIGLETS; TIGHT junctions; GUT microbiome; FOOD additives; ZINC oxide; TRIMETHYLAMINE oxide
- Publication
Journal of the Science of Food & Agriculture, 2021, Vol 101, Issue 2, p735
- ISSN
0022-5142
- Publication type
Article
- DOI
10.1002/jsfa.10686