We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors.
- Authors
Maximino, Caio; da Silva, Annanda Waneza Batista; Araújo, Juliana; Lima, Monica Gomes; Miranda, Vanessa; Puty, Bruna; Benzecry, Rancés; Picanço-Diniz, Domingos Luiz Wanderley; Gouveia Jr, Amauri; Oliveira, Karen Renata Matos; Herculano, Anderson Manoel
- Abstract
A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for drugs which alter anxiety-like behavior in adult zebrafish. The observed phenotypes were clustered according to shared behavioral effects. This barcoding procedure revealed conserved functions of anxiolytic, anxiogenic and psychomotor stimulating drugs and predicted effects of poorly characterized compounds on anxiety. Moreover, anxiolytic drugs all decreased, while anxiogenic drugs increased, serotonin turnover. These results underscore the power of behavioral profiling in adult zebrafish as an approach which combines throughput and physiological complexity in the pharmacological dissection of complex behaviors.
- Subjects
PSYCHIATRIC drugs; ZEBRA danio; ANXIETY; FISH behavior; BIOLOGICAL assay; PSYCHOMOTOR disorders
- Publication
PLoS ONE, 2014, Vol 9, Issue 7, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0103943