We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cytohesins/ARNO: The Function in Colorectal Cancer Cells.
- Authors
Pan, Tao; Sun, Junfeng; Hu, Jiyi; Hu, Yiwang; Zhou, Jun; Chen, Zhigang; Xu, Dong; Xu, Wenhong; Zheng, Shu; Zhang, Suzhan
- Abstract
Epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) are critical regulators of cell differentiation, survival, proliferation, and migration in cancers. This study found that ARNO (cytohesin-2), an activator of the EGF and IGF-I pathways, was more highly expressed in colorectal cancer tissue than in benign adjacent colorectal tissue. When ARNO-siRNA or the chemical inhibitor SecinH3 blocked ARNO, the downstream of the EGF and IGF-I pathways decreased in colorectal cell lines HT29 and HCT116. This blocking also weakened cell proliferation, invasion, and migration in vitro. Furthermore, EGF receptor (EGFR)-dependent colorectal tumor xenografts in nude mouse exerted anti-proliferative and growth suppression effects by injecting secineH3. These data suggested that inhibiting cytohesins or ARNO as cytoplasmic activators of EGFR and IGF-I in colorectal cancer resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth in vivo and in vitro. Therefore, cytohesins or ARNO may be a potential therapy target for some colorectal cancer.
- Subjects
CYTOHESINS; COLON cancer; CANCER cells; EPIDERMAL growth factor; SOMATOMEDIN C; CANCER cell migration; CANCER cell proliferation
- Publication
PLoS ONE, 2014, Vol 9, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0090997