We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Predictors of Beta-Blocker Intolerance and Mortality in Patients After Acute Coronary Syndrome.
- Authors
De Stefano, Laercio Martins; Ferraz, Alex Lombardi Barbosa; Ferreira, Ana Lúcia dos Anjos; Gut, Ana Lúcia; Cogni, Ana Lúcia; Farah, Elaine; Matsubara, Beatriz Bojikian
- Abstract
Purpose:To investigate the predictors of intolerance to beta-blockers treatment and the 6-month mortality in hospitalized patients with acute coronary syndrome (ACS). Methods:This was a single-center, prospective, and longitudinal study including 370 consecutive ACS patients in Killip class I or II. BBs were prescribed according to international guidelines and withdrawn if intolerance occurred. The study was approved by the institutional ethics committee of our university. Statistics: the clinical parameters evaluated at admission, and the related intolerance to BBs and death at 6 months were analyzed using logistic regression (p<0.05)in PATIENTS. Results:BB intolerance was observed in 84 patients and was associated with no prior use of statins (OR: 2.16, 95%CI: 1.26–3.69, p= 0.005) and Killip class II (OR: 2.5, 95%CI: 1.30-4.75, p=0.004) in the model adjusted for age, sex, blood pressure, and renal function. There was no association with ST-segment alteration or left anterior descending coronary artery plaque. Intolerance to BB was associated with the greatest risk of death (OR: 4.5, 95%CI: 2.15–9.40, p<0.001). Conclusions:After ACS, intolerance to BBs in the first 48 h of admission was associated to non previous use of statin and Killip class II and had a high risk of death within 6 months.
- Subjects
ADRENERGIC beta blockers; HOSPITAL mortality; ACUTE coronary syndrome; HEART disease related mortality; DEATH rate; HOSPITAL admission &; discharge; REGRESSION analysis
- Publication
PLoS ONE, 2013, Vol 8, Issue 10, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0077747