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- Title
Potential Therapy from Punica granatum Peel Extract for the Treatment of Recurrent Aphthous Stomatitis. Design, Formulation and Characterisation of a Mucoadhesive Patch.
- Authors
AHi Wahid, Rahmat; Lailli D., Vella
- Abstract
Recurrent aphthous stomatitis (RAS) is an inflammation that occurs in oral mucosa. Etiology of RAS may be caused by several factors involving systemic conditions, local, microbes (Candida albicans), moniliasis, hygiene and genetics. Several studies has shown that pomegranate (Punica granatum L.) peel serves to inhibit Candida albicans, antibacterial Staphylococcus aureus, Staphylococcus mutans, Escherichia coli and antifungal Aspergillus niger, which is common microorganisms involved in dental and oral problems. This study aims to formulate a pomegranate peel extracts (PPE) mucoadhesive patch and test its effectiveness in healing sores. PPE obtained from the maceration method. Polyvinylpyrrolidone patch formulations, chitosan and Hydroxypropyl Methyl Cellulose (HPMC) using a ratio of 1:1, 2:1, and 3:1 weight/volume. Patch tested his physical characteristics, including weight uniformity, uniformity of dimension, thickness, surface pH, swelling and adhesion test, and in vivo test. The F8 formulation of PPE 10% with the addition of HPMC, tween, and glycerin have a fairly elastic properties. Even though experiment of physical evaluation produce uniformity of same weights and dimensions, pH 6.63, an average of swelling percentage 40.69% ± 16.37% and an average of stickness 13.50 ± 11.6 seconds. In vivo test show that formulation of PPE 10% has the same effectivity in reducing the diameter of the mouth ulcers with the positive control group.
- Subjects
DRUG efficacy; POMEGRANATE; CANKER sores; IN vivo studies; CONTROLLED release preparations; DESCRIPTIVE statistics; PLANT extracts; PHARMACEUTICAL chemistry
- Publication
Medico-Legal Update, 2021, Vol 21, Issue 3, p458
- ISSN
0971-720X
- Publication type
Article
- DOI
10.37506/mlu.v21i3.3031