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- Title
Transition‐Metal‐Free Selective Iodoarylation of Pyrazoles via Heterocyclic Aryliodonium Ylides.
- Authors
Lu, Nannan; Huang, Liangsen; Xie, Lili; Cheng, Jiajia
- Abstract
A one‐pot transition‐metal‐free selective iodoarylation of pyrazoles with aryliodine diacetates has been developed. The reaction proceeds via the generation of NH‐pyrazole‐iodonium salts in situ, followed by sequential phen/K2CO3‐mediated intermolecular arylation. When the iodonium ylide was directly used as substrate, the difunctionalization products could be prepared in high yield under base‐ and metal‐free conditions. This transformation provides an efficient route to high‐value multisubstituted pyrazole derivatives from simple and readily available substrates.
- Subjects
TRANSITION metal compounds synthesis; PYRAZOLE derivatives; HETEROCYCLIC compounds; INTERMOLECULAR interactions; IODONIUM salts; CELL transformation
- Publication
European Journal of Organic Chemistry, 2018, Vol 2018, Issue 26, p3437
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201800416