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- Title
Efectos renales adversos por inhibidores del check-point (ICP) en pacientes con cáncer. Recomendaciones del grupo de Onconefrología de la Sociedad Española de Nefrología (SEN).
- Authors
Alonso, Fabiola; Martín de Francisco, Ángel L. M.; Auñón, Pilar; García-Carro, Clara; García, Patricia; Gutiérrez, Eduardo; Macía, Manuel; Quintana, Luis F.; Quiroga, Borja; José Soler, María; Torregrosa, Isidro
- Abstract
The most widely used approach in the immunotherapy treatment of cancer is the administration of monoclonal antibodies directed against regulatory molecules of immune control that inhibit the activation of T cells, the so-called check point inhibitors (ICI). ICI nephrotoxicity epidemiology and pathology; its diagnosis with or without kidney biopsy; the type and duration of treatment; the possibility of rechallenging after kidney damage; and its indication in patients with cancer and renal transplantation are certainly controversial. In the absence of definitive studies, this document is intended to specify some recommendations agreed by the group of onconephrology experts of the Spanish Society of Nephrology in those areas related to ICI nephrotoxicity, in order to help decision-making in daily clinical practice in onconephrology consultations.
- Subjects
KIDNEY transplantation; RENAL biopsy; MONOCLONAL antibodies; IMMUNE checkpoint inhibitors; T cells
- Publication
Nefrologia, 2023, Vol 43, Issue 5, p622
- ISSN
0211-6995
- Publication type
Article
- DOI
10.1016/j.nefro.2022.12.004