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- Title
Oral Cryotherapy for Oral Mucositis in Patients Receiving Busulfan: A Retrospective/ Prospective Descriptive Study.
- Authors
Grossman, Azure; Froggatt, Nancy; Hendricks, Lauren; Kannenberg, Melinda; Klink, Katharine; Koch, Nicholas; Reid, Kelli; Pitcher, Dean; Bullock, Peter; Neubauer, Jolie
- Abstract
OBJECTIVES: To determine whether oral cryotherapy (OC) mitigates oral mucositis (OM) resulting from busulfan chemotherapy. SAMPLE & SETTING: Electronic health records of patients undergoing busulfan conditioning for blood and marrow transplantation were reviewed for this descriptive study. The post-OC group received OC with busulfan, but the pre-OC group did not. METHODS & VARIABLES: Demographic and disease characteristics for both groups were summarized using descriptive statistics. Wilcoxon rank-sum test was performed for continuous and ordinal measures, and chi-square tests were performed for categorical outcomes between the two groups. RESULTS: This study found a decrease in the severity of OM as assessed by the World Health Organization OM scale. This study also found a reduction of total parenteral nutrition and opioid pain medication use, as well as a decrease in length of stay and airway protection–related intensive care unit transfers. An increase in day 11 methotrexate administration for graft-versus-host disease prophylaxis was observed in the post-OC group. IMPLICATIONS FOR NURSING: OC is a safe and easily implemented intervention that can decrease OM in patients receiving busulfan chemotherapy.
- Subjects
STOMATITIS treatment; LENGTH of stay in hospitals; STOMATITIS; ACADEMIC medical centers; BONE marrow transplantation; COLD therapy; RESEARCH methodology; RETROSPECTIVE studies; ACQUISITION of data; MANN Whitney U Test; PATIENTS; TREATMENT effectiveness; SEVERITY of illness index; METHOTREXATE; MEDICAL records; DESCRIPTIVE statistics; CHI-squared test; BUSULFAN; STATISTICAL sampling; PARENTERAL feeding; LONGITUDINAL method; TRANSPLANTATION of organs, tissues, etc.; PAIN management; EVALUATION
- Publication
Oncology Nursing Forum, 2022, Vol 49, Issue 4, p327
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/22.ONF.327-335