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- Title
Research Submissions Familial Migraine With Aura: Association Study With 5-HT<sub>1B/1D</sub>, 5-HT<sub>2C</sub>, and hSERT Polymorphisms.
- Authors
Racchi, Marco; Leone, Massimo; Porrello, Emanuela; Rigamonti, Andrea; Govoni, Stefano; Sironi, Marita; Montomoli, Cristina; Bussone, Gennaro
- Abstract
Background.—The serotonergic system has a significant role in the pathophysiology and pharmacology of migraine. Objective.—To study the association between the occurrence of migraine with aura and 5-HT1B/1D and 5-HT2C receptor gene and the human serotonin transporter (hSERT) gene polymorphisms in 18 unrelated families with multiple affected members. Method.—Two polymorphisms in the 5-HT1B/1D receptor gene and one polymorphism in the 5-HT2C receptor gene were studied by restriction fragment length polymorphism analysis. Allelic variation of the hSERT, with 9, 10, and 12 copies of a “repetitive element,” was studied by polymerase chain reaction amplification of the variable number tandem repeat region. Results.—Allelic distribution of 5-HT1B/1D and 5-HT2C receptor gene polymorphisms in affected patients did not differ in either of the control groups (unaffected relatives or unrelated healthy individuals). A trend toward a significant effect of the 12-repeat hSERT allele as a risk factor for migraine with aura versus unrelated controls was observed. Conclusion.—Our data do not support the involvement of 5-HT1B/1D and 5-HT2C receptor gene polymorphisms in migraine with aura, yet do suggest a possible role for a locus at or near the hSERT gene in the susceptibility to migraine with aura.
- Subjects
MIGRAINE; SEROTONIN; GENETIC polymorphisms; POLYMERASE chain reaction; DISEASE susceptibility; GENES
- Publication
Headache: The Journal of Head & Face Pain, 2004, Vol 44, Issue 4, p311
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/j.1526-4610.2004.04072.x