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- Title
A Polymorphism of Intercellular Adhesion Molecule--1 Is Associated with a Reduced Incidence of Nonmalarial Febrile Illness in Kenyan Children.
- Authors
Jenkins, Neil E.; Mwangi, Tabitha W.; Kortok, Moses; Marsh, Kevin; Craig, Alister G.; Williams, Thomas N.
- Abstract
An intercellular adhesion molecule-1 polymorphism (ICAM-1Kilifi) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1Kilifi. We propose that ICAM-1Kilifi may be associated with reduced rates of tissue damage and of death due to sepsis.
- Subjects
CELL adhesion molecules; CEREBRAL malaria; SEPSIS; FEVER in children; GENETIC polymorphisms; PROTOZOAN diseases
- Publication
Clinical Infectious Diseases, 2005, Vol 41, Issue 12, p1817
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/498156