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- Title
Rola witaminy D<sub>3</sub> w patogenezie przewlekłego zapalenia zatok przynosowych.
- Authors
TOMASZEWSKA, MAŁGORZATA; ZAGOR, MARIOLA; RUSETSKA, NATALIA; KRZESKI, ANTONI
- Abstract
Introduction. Chronic rhinosinusitis (CRS) is a common inflammatory disorder that is a challenging therapeutic problem. One of the theories behind the CRS pathophysiology is the idea that deficiency of vitamin D3 influences innate immune functions in the paranasal sinuses. Aim. 1. Assessment of total and active amount of vitamin D3 in sera of CRS patients with (CRSwNP) and without nasal polyps (CRSsNP) and in healthy controls (HC). 2. Correlation of results with clinical data, i.e. SNOT-20 questionnaire, CT scan, presence of asthma, vitamin D3 supplemantation. Material and methods. The research comprised 114 patients. The sera level of 25(OH)D3 and 1.25(OH)2D3 was estimated in 48 HC, 32 patients with CRSsNP, 34 patients with CRSsNP with the average age 43 years. All patients were evaluated clinically according to the Lund-Mackay CT score, SNOT-20. Results. There is suboptimal status of 25(OH)D3 level and target concentration of 1,25(OH)2D3 in all studied groups, without statistically significant differences between the groups (p>0.05) and seasons of the year (p>0.05). The sera level of 25(OH)D3 and 1.25(OH)2D3 does not correlate with Lund-Mackay CT score, SNOT-20 and vitamin D3 supplementation. Conclusions. Our data provided the evidence that there is suboptimal status of 25(OH)D3 level in all studied groups. There is a need for further research on D3-reliant molecular mechanisms in paranasal sinuses mucosa.
- Publication
Otorynolaryngologia, 2016, Vol 15, Issue 1, p33
- ISSN
1643-658X
- Publication type
Article