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- Title
Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression.
- Authors
Merendino, Rosaria Alba; di Pasquale, Giuseppe; de Luca, Filippo; di Pasquale, Laura; Ferlazzo, Edoardo; Martino, Gabriella; Palumbo, Maura Carmela; Morabito, Fortunato; Gangemi, Sebastiano
- Abstract
M oderate -severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1α) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP-1α in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP-1α was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.
- Subjects
IMMUNOSUPPRESSION; MACROPHAGES; CYTOKINES; CHEMOKINES; INFLAMMATORY mediators; IMMUNOREGULATION; CENTRAL nervous system; IMMUNOCYTOCHEMISTRY
- Publication
Mediators of Inflammation, 2004, Vol 13, Issue 3, p205
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1080/09511920410001713484