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- Title
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells.
- Authors
Maruyama, Hidekazu; Sakai, Satoshi; Ieda, Masaki
- Abstract
The article reviews the study on the effects of endothelin-1 (ET-1) on bone morphogenetic protein (BMP) receptor expression and cell proliferation in patients with Pulmonary arterial hypertension. BMP2 increased BMPR1B expression in human pulmonary artery smooth muscle cells (PASMCs) after pretreatment with ET-1 in vitro. BMP2 treatment after ET-1 pretreatment significantly accelerated PASMC proliferation. PH-797804, a selective p38MAPK inhibitor, abrogated this proliferation.
- Publication
Canadian Journal of Physiology & Pharmacology, 2022, Vol 100, Issue 10, p1018
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2022-0104