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- Title
Quercetin prevents experimental glucocorticoid-induced osteoporosis: a comparative study with alendronate.
- Authors
Derakhshanian, Hoda; Djalali, Mahmoud; Djazayery, Abolghassem; Nourijelyani, Keramat; Ghadbeigi, Sajad; Pishva, Hamideh; Saedisomeolia, Ahmad; Bahremand, Arash; Dehpour, Ahmad Reza
- Abstract
Glucocorticoid-induced osteoporosis (GIO) is the most common type of secondary osteoporosis. The aim of this study was to compare the efficacy of quercetin, a plant-derived flavonoid, with alendronate in the prevention of GIO. Fifty-six Sprague-Dawley rats were randomly distributed among 7 groups (8 rats per group) and treated for 6 weeks with one of the following: ( i) normal saline; ( ii) 40 mg methylprednisolone sodium succinate (MP)/kg body mass; ( iii) MP + 40 μg alendronate/kg; ( iv) MP + 50 mg quercetin/kg; ( v) MP + 40 μg alendronate/kg + 50 mg quercetin/kg; ( vi) MP + 150 mg quercetin/kg; and ( vii) MP + 40 μg alendronate/kg + 150 mg quercetin/kg. MP and alendronate were injected subcutaneously and quercetin was administered by oral gavage 3 days a week. At the end of the study, femur breaking strength was significantly decreased as a consequence of MP injection. This decrease was completely compensated for in groups receiving 50 mg quercetin/kg plus alendronate, and 150 mg quercetin/kg with or without alendronate. Quercetin noticeably elevated osteocalcin as a bone formation marker, while alendronate did not show such an effect. In addition, administration of 150 mg quercetin/kg increased femoral trabecular and cortical thickness by 36% and 22%, respectively, compared with the MP-treated group. These data suggest that 150 mg quercetin/kg, alone or in combination with alendronate, can completely prevent GIO through its bone formation stimulatory effect.
- Subjects
QUERCETIN; GLUCOCORTICOIDS; OSTEOPOROSIS prevention; FLAVONOIDS; METHYLPREDNISOLONE
- Publication
Canadian Journal of Physiology & Pharmacology, 2013, Vol 91, Issue 5, p380
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2012-0190