We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cytochrome p450 enzymes and cardiovascular disease.
- Authors
Hunter, Arwen L.; Cruz, Rani P.; Cheyne, Bo M.; McManus, Bruce M.; Granville, David J.
- Abstract
The cytochrome p450 (CYP) superfamily is responsible for the oxidation, peroxidation, and (or) reduction of vitamins, steroids, xenobiotics, and the majority of cardiovascular drugs in an oxygen- and NADPH-dependent manner. Although hepatic CYP have been studied extensively, the role of CYP in cardiovascular physiology and disease is poorly understood. Increasing evidence suggests that these enzymes play an important role in the pathogenesis of a number of cardiovascular diseases. The current review summarizes the understanding as to the role that dysregulated CYP expression and (or) activity may play in the onset and progression of cardiovascular disease.
- Subjects
CYTOCHROMES; HEMOPROTEINS; BIOLOGICAL pigments; ENZYMES; CARDIOVASCULAR diseases
- Publication
Canadian Journal of Physiology & Pharmacology, 2004, Vol 82, Issue 12, p1053
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/y04-118