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- Title
Improved large-scale synthesis and characterization of small and medium generation PAMAM dendrimers.
- Authors
Ficker, Mario; Paolucci, Valentina; Christensen, Jørn B.
- Abstract
Dendrimers are promising polymers for biomedical applications; however, most dendrimer formulations have failed to move from laboratory science to upscaled products for preclinical testing or GMP production. This publications reports on an improved large-scale PAMAM dendrimer synthesis that is suitable to manufacture large amounts of highly pure and monodisperse dendrimers of generations G0-G5. Furthermore, an extended analytical guideline how to characterize PAMAM dendrimers with NMR, HPLC, SEC-MALS, ESI, MALDI, UV-vis, fluorescence, and IR spectroscopy is provided.
- Subjects
DENDRIMERS; POLYMERS; BIOMEDICAL materials; CURRENT good manufacturing practices; FLUORESCENCE; INFRARED spectroscopy
- Publication
Canadian Journal of Chemistry, 2017, Vol 95, Issue 9, p954
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2017-0108