We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Scaleable and Defined System for Generating Neural Stem Cells from Human Embryonic Stem Cells.
- Authors
Joannides, Alexis J.; Fiore-Hériché, Christelle; Battersby, Alysia A.; Athauda-Arachchi, Pandula; Bouhon, Isabelle A.; Williams, Lydia; Westmore, Kristine; Kemp, Paul J.; Compston, Alastair; Allen, Nicholas D.; Chandran, Siddharthan
- Abstract
The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable, and widely applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations, or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications.
- Subjects
EMBRYONIC stem cells; NEURAL stem cells; STEM cells; GENE expression; THERAPEUTICS; DEVELOPMENTAL genetics
- Publication
Stem Cells, 2007, Vol 25, Issue 3, p731
- ISSN
1066-5099
- Publication type
Article
- DOI
10.1634/stemcells.2006-0562