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- Title
Persistence of Cell-Mediated Immunity and Decline of Humoral Immunity to the Intracellular Bacterium Francisella tularensis 25 Years after Natural Infection.
- Authors
Ericsson, Mats; Sandström, Gunnar; Sjöstedt, Anders; Tärnvik, Arne
- Abstract
The humoral and cell-mediated immune responses to the facultative intracellular pathogen Francisella tularensis were studied in subjectswho had tularemia 25 years earlier. Serum agglutinin titers were low. Of 53 subjects, only 2 had a titer >40. The F. tularensis-induced T cell response, on the other hand, was vigorous and in fact similar in magnitude to the response to purified protein derivative (PPD) of Mycobacterium tuberculosis, T cells.from 44 of 52 subjects showed a significant (P < .05) proliferative response in vitro to each of four membrane proteins of F. tularensis. Only 2 subjects did not respond to any of the proteins, In most cultures from 18 subjects tested, interferon-γ was produced in response to the proteins. During the last 25 years, tularemia has been reported only rarely in the region where the subjects lived, suggesting that an antigen-specific T cell response may persist after tularemia independently of reexposure to F. tularensis.
- Publication
Journal of Infectious Diseases, 1994, Vol 170, Issue 1, p110
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/170.1.110