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- Title
Autoimmune haemolytic anaemia associated with COVID‐19 infection.
- Authors
Lazarian, Gregory; Quinquenel, Anne; Bellal, Mathieu; Siavellis, Justine; Jacquy, Caroline; Re, Daniel; Merabet, Fatiha; Mekinian, Arsene; Braun, Thorsten; Damaj, Gandhi; Delmer, Alain; Cymbalista, Florence
- Abstract
Autoimmune haemolytic anaemia associated with COVID-19 infection Keywords: COVID-19; autoimmune hemolytic anemia; B-cell lymphoproliferative disorder EN COVID-19 autoimmune hemolytic anemia B-cell lymphoproliferative disorder 29 31 3 07/01/20 20200701 NES 200701 Among patients with SARS-CoV-2 infection (also known as COVID-19), pneumonia, respiratory failure and acute respiratory distress syndrome are frequently encountered complications.[1] Although the pathophysiology underlying severe COVID-19 remains poorly understood, accumulating evidence argues for hyperinflammatory syndrome causing fulminant and fatal cytokines release associated with disease severity and poor outcome.[2] However, the spectrum of complications is broader and includes among others various auto-immune disorders such as autoimmune thrombocytopenia, Guillain-Barré and antiphospholipid syndrome.[[3], [5]] In this report we describe seven patients from six French and Belgian Hospitals who developed a first episode of autoimmune haemolytic anaemia (AIHA) during a COVID-19 infection. Patient characteristics are detailed in Table I. Briefly, median age was 62 years (range, 61-89 years), and all patients presented with risk factors for developing a severe form of COVID-19 such as hypertension, diabetes and chronic renal failure. Corticosteroid failure lead to rituximab injection in the third case (patient #6), and one responding patient is scheduled to receive rituximab because of a MZL clone (patient #3).
- Subjects
AUTOIMMUNE hemolytic anemia; COVID-19; HEMOLYTIC anemia
- Publication
British Journal of Haematology, 2020, Vol 190, Issue 1, p29
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.16794