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- Title
The prognostic value of interim positron emission tomography scan in patients with classical Hodgkin lymphoma.
- Authors
Oki, Yasuhiro; Chuang, Hubert; Chasen, Beth; Jessop, Aaron; Pan, Tinsu; Fanale, Michelle; Dabaja, Bouthaina; Fowler, Nathan; Romaguera, Jorge; Fayad, Luis; Hagemeister, Fredrick; Rodriguez, Maria Alma; Neelapu, Sattva; Samaniego, Felipe; Kwak, Larry; Younes, Anas
- Abstract
The prognostic value of interim positron emission tomography ( PET) was evaluated after 2 cycles of doxorubicin, bleomycin, vinblastin and dacarbazine in classical Hodgkin lymphoma patients ( n = 229), based on Deauville criteria. In early stage non-bulky disease, bulky stage II disease, advanced stage low International Prognostic Score ( IPS ≤2) and advanced stage ( IPS ≥3), 3-year progression-free survival rates in PET2-negative vs. PET2-positive groups were 95·9% vs. 76·9% ( P < 0·0018), 83·3% vs. 20·0% ( P = 0·017), 77·0% vs. 30·0% ( P < 0·001) and 71·0% vs. 44·4%( P = 0·155), respectively. The outcome after positive PET2 was better than previously reported. The results from non-randomized studies of PET2-guided therapy would be valuable with careful interpretation.
- Subjects
HODGKIN'S disease; POSITRON emission tomography; DOXORUBICIN; BLEOMYCIN; VINBLASTINE; DISEASE progression; PROGNOSIS
- Publication
British Journal of Haematology, 2014, Vol 165, Issue 1, p112
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12715