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- Title
Evaluation of the Biological Significance of Leukocyte Infiltration of the Thyroid in Graves' Disease.
- Authors
Levis, Silvina; Ghandur-Mnaymneh, Latifa; McKenzie, Maxwell; Zakarija, Margita
- Abstract
Graves' goiter size and gland function may be affected by interferon-γ influencing actions of the thyroid-stimulating antibody. Goiter weight (n = 20), lymphocytic infiltration and class II antigen expression were assessed. The largest goiters, strikingly, has least infiltration but, overall, the looked-for negative correlation between goiter size and lymphocyte infiltration did not materialize. This was presumably due, in part, to inhibiting antibodies in many (8/18) patients' sera. In addition, our data do not support a major pathogenetic role for class II antigen in Graves' disease. Copyright © 1992 S. Karger AG, Basel
- Publication
International Archives of Allergy & Immunology, 1992, Vol 99, Issue 1, p37
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000236333