We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells.
- Authors
Portella, Giuseppe; Pacelli, Roberto; Libertini, Silvana; Cella, Laura; Vecchio, Giancarlo; Salvatore, Marco; Fusco, Alfredo
- Abstract
ONYX-015 is a genetically modified adenovirus with a deletion of the E1B early gene and therefore is designed to replicate preferentially in p53-mutated cells causing their death. We previously demonstrated that the ONYX-015 virus kills anaplastic thyroid carcinoma (ATC) cells and enhances the antineoplastic effects of doxorubicin and paclitaxel. Here we report that ONYX-015 increased the cytopathic effect of radiotherapy in three ATC cell lines. In fact, ONYX-015 and radiation induced a significant cytopathic effect on ATC cells. DNA fragmentation analysis showed that ATC ONYX-015-treated cells were very sensitive to radiation-induced apoptosis. In addition, low doses of ONYX-015 associated with a single radiation dose of 10 Gy delayed the growth of a xenograft tumor induced by ARO cells in athymic mice. Our results suggest that the combination of ONYX-015 and radiotherapy should be considered for experimental trials in patients with anaplastic thyroid carcinoma.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2003, Vol 88, Issue 10, p5027
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2003-030385